Orally active adenosine kinase inhibitors

Details Orally active adenosine kinase inhibitors Orally active adenosine kinase inhibitors

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) C07H 19/04 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2247984

This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo[2,3-d] pyrimidine and 3-aryl pyrazolo[3,4-d] pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention also relates to the preparation and use of these and other adenosine kinase inhibitors in the treatment of cardiovascular and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.

L'invention concerne des inhibiteurs d'adénosine kinase et des analogues de nucléosides, et spécifiquement les analogues de nucléosides 5-aryl pyrrolo(2,3-d) pyrimidine et 3-aryl pyrazolo(3,4-d) substitués, oralement actifs, présentant une activité en tant qu'inhibiteurs d'adénosine kinase. L'invention concerne également la préparation et l'utilisation de ces inhibiteurs d'adénosine kinase et d'autres inhibiteurs pour le traitement de maladies cardiovasculaires et cérébrovasculaires, de maladies inflammatoires et d'autres maladies qu'on peut réguler en augmentant la concentration locale d'adénosine.

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