C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/415 (2006.01) A61K 36/42 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 3/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2285452
A water soluble extract of M. charantia named MC6, methods for its preparation and methods for its use in the treatment of hyperglycemic disorders are provided. The activate MC6 is characterized by moving as a single band on SDS- PAGE having a molecular weight of less than 10 kDal, and by comprising three peptides. Also provided is a peptide component of MC6 named MC6.1, as well as analogues and mimetics thereof. The active MC6, MC6.1, MC6.2, and MC6.3 exhibit hypoglycemic activity, even following oral administration, also provided are methods of using the active agents to treat hyperglycemic disorders, particularly diabetes, where the active agents are preferably orally administered.
L'invention porte sur un extrait hydrosoluble de M. Charantia, dit MC6, ses procédés de préparation, et son utilisation pour le traitement des troubles liés à l'hyperglycémie, le MC6 qui se déplace en formant une bande unique sur le SDS- PAGE a un poids moléculaire de moins de 10 kDa et comprend 3 peptides. L'invention porte également sur un composant du MC6, dit MC6.1 et sur ses analogues et mimétiques. Les MC6, MC6.1, MC6.2 et MC6.3 ont une action hypoglycémiante, même après administration orale. L'invention porte en outre sur des méthodes d'utilisation de ces agents pour le traitement des troubles liés à l'hyperglycémie, et en particulier du diabète, les agents actifs étant de préférence administrés par voie orale.
Medicherla Satyanarayana
Nag Bishwajit
Sharma Somesh D.
Calyx Therapeutics Inc.
Smart & Biggar
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