Orally active nonaddicting analgesics

Details Orally active nonaddicting analgesics Orally active nonaddicting analgesics

C - Chemistry, Metallurgy

07

D

167/227, 260/237

C07D 489/02 (2006.01) A61K 31/485 (2006.01)

Patent

CA 1313868

Abstract Stereoisomerically pure forms of normorphine analogs which have superior or analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl- substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent. The invention relates to compounds of the formula: Image (1) and the pharmaceutically acceptable acid addition salts thereof. wherein Y is OH or OMe; the dotted line indicates the presence or absence of a .pi. bond; X is -OH or =0; with the proviso that the dotted line indicates a .pi. bond, X must be OH; and wherein the compound of Formula 1 is in a stereoisomerically pure form which corresponds to that of N-.alpha.-methylcyclopropylmethyl normorphine which melts at 188-189°C.

532714

Affiliated with

Also associated with

Rating

Orally active nonaddicting analgesics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Orally active nonaddicting analgesics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orally active nonaddicting analgesics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1238373