Orally active phosphonyl hydroxyacyl prolines and processes...

Details Orally active phosphonyl hydroxyacyl prolines and processes... Orally active phosphonyl hydroxyacyl prolines and processes...

C - Chemistry, Metallurgy

07

F

167/233, 260/325

C07F 9/572 (2006.01) A61K 31/66 (2006.01)

Patent

CA 1279651

ABSTRACT ORALLY ACTIVE PHOSPHONYL HYDROXYACYL PROLINES AND PROCESSES FOR PREPARING PHOSPHONYL HYDROXYACYL PROLINES Processes are disclosed for preparing phosphonyl hydroxyacyl prolines from a phosphonous acid or phosphonochloridate intermediate. The compounds prepared possess angiotension converting enzyme inhibition activty and are useful as anti- hypertensive agents. This invention is also directed to orally active antihypertensive agents of the formula Image wherein R1 is certain alkyl or aralkyl groups.

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