Orally active salts with tyrosine kinase activity

Details Orally active salts with tyrosine kinase activity Orally active salts with tyrosine kinase activity

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/337 (2006.01) A61K 31/4465 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61K 39/395 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2424689

The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

L'invention concerne des sels de composés oralement actifs, qui inhibent, régulent ou modulent la transduction de signal de la tyrosine kinase. L'invention concerne également des compositions contenant ces composés, ainsi que des procédés d'utilisation de ces sels pour traiter des maladies et des états associés à la tyrosine kinase, tels que l'angiogenèse, le cancer, la croissance tumorale, l'athérosclérose, la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique, des maladies inflammatoires et des pathologies similaires chez les mammifères.

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