Orally-administered agent

Details Orally-administered agent Orally-administered agent

A - Human Necessities

61

K

A61K 47/32 (2006.01) A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2700480

An orally-administered agent comprised of a laminated body having surface layers is provided. The laminated body comprises a medicine-containing layer containing a medicine and having surfaces; and at least one gel-forming layer provided on one of the surfaces of the medicine-containing layer as one of the surface layers of the laminated body. The at least one gel-forming layer includes a gel-forming agent to be swelled and gelatinized when absorbing a water-based liquid. A water absorption speed per 1 g of the gel-forming layer with respect to water of 37°C is 0.5 g/(g.cndot.s) or higher. A gel fraction of the gel-forming layer is 20 mass% or more when the gel-forming layer is dipped into an aqueous solution of 0.9 mass% of sodium chloride having a temperature of 37°C.

L'invention porte sur une préparation médicinale pour une administration orale qui présente une structure multicouche comportant une couche contenant un médicament et une couche formant un gel. La structure multicouche comprend la couche formant un gel disposée en tant que couche de surface de chaque côté. La couche formant un gel contient un agent de création de gel qui, lors de l'absorption d'un liquide aqueux, gonfle pour donner un gel. La couche formant un gel présente une vitesse d'absorption de l'eau d'au moins 0,5 g/(g s) à 37 °C et une teneur finale en gel, déterminée par l'immersion dans une solution aqueuse à 0,9 % en masse de chlorure de sodium à 37 °C, d'au moins 20 % en masse.

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