Orally-administered agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 9/00 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2719921

An orally-administered agent according to the present invention comprises: a medicine-containing layer containing a medicine and having surfaces; collapse--controlling layers respectively provided on the surfaces of the medicine-containing layer; and gel-forming layers respectively provided on the collapse-controlling layers, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The collapse-controlling layers are constituted of a material containing a stomach--soluble material to be dissolved by being in contact with gastric juice. The orally-administered agent according to the present invention can be swallowed with ease and release the medicine in intended parts, in particular, the stomach of a living body.

La préparation orale de la présente invention comporte les éléments suivants : une couche de médicament qui renferme ledit médicament ; des couches de contrôle de désintégration prévues sur les deux surfaces de la couche de médicament ; et des couches de formation de gel prévues sur chaque couche de contrôle de désintégration de la couche de médicament, qui se gonflent en absorbant de l'eau pour former un gel. Chaque couche de contrôle de désintégration est caractérisée par le fait qu'elle se compose de matériaux incluant un matériau gastrosoluble qui se dissout lorsqu'il est en contact avec les sucs gastriques. La préparation orale de la présente invention est facile à avaler et peut libérer le médicament dans des sites ciblés du corps, en particulier dans l'estomac.

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