Orally administered peptides synergize statin activity

Details Orally administered peptides synergize statin activity Orally administered peptides synergize statin activity

A - Human Necessities

61

K

A61K 38/02 (2006.01) A61K 38/03 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/775 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2501943

This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high-density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the station permitting the station to be used at significantly lower dosages and/or cause the stations to be significantly more anti- inflammatory at any given dose.

Cette invention concerne de nouveaux peptides améliorant un ou plusieurs symptômes de l'athérosclérose. Ces peptides sont hautement stables et s'administrent facilement par voie orale. Les peptides de l'invention sont efficaces pour stimuler la formation et la circulation de particules pré-béta apparentées à la lipoprotéine de haute densité et/ou promouvoir le transport et/ou la détoxification des lipides. L'invention concerne également un procédé de recherche d'un peptide chez un mammifère. De plus, les peptides de l'invention inhibent l'ostéoporose. Lorsqu'ils sont administrés en association ave une statine, ces peptides améliorent l'activité de la statine et permettent de l'utiliser à des doses considérablement inférieures et/ou en améliorent sensiblement les propriétés anti-inflammatoires à n'importe quelle dose donnée.

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