Orally administered small peptides synergize statin activity

Details Orally administered small peptides synergize statin activity Orally administered small peptides synergize statin activity

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01)

Patent

CA 2534676

This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose.

L'invention concerne de nouveaux peptides capables d'améliorer un ou plusieurs symptômes d'athérosclérose. Les peptides sont d'une haute stabilité et peuvent être facilement administrés par voie orale. Les peptides sont efficaces pour stimuler la formation et la cyclisation de particules de type lipoprotéine haute densité, pré-béta et/ou favoriser le transport de lipides et la désintoxication. L'invention concerne également un procédé de localisation d'un peptide chez un mammifère. En outre, les peptides inhibent l'ostéoporose. Lorsqu'ils sont administrés avec une statine, les peptides améliorent l'activité de la statine, permettant ainsi que la statine soit utilisée à des dosages bien plus faibles, les statines exerçant ainsi, par ailleurs, une action bien plus anti-inflammatoire à une dose quelconque.

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