Orally administered small peptides synergize statin activity

Details Orally administered small peptides synergize statin activity Orally administered small peptides synergize statin activity

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2577026

This invention provides novel small molecules that ameliorate one or more symptoms of atherosclerosis. The small molecules are highly stable and readily administered via an oral route. The small molecules are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a small molecule in a mammal. In addition, the small molecules inhibit osteoporosis. When administered with a statin, the small molecules enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose.

L'invention concerne de nouvelles petites molécules destinées à améliorer un ou plusieurs symptômes de l'athérosclérose. Ces petites molécules sont très stables et facilement administrées par voie orale. Lesdites petites molécules stimulent efficacement la formation et le cycle de particules pré-béta de haute densité semblables aux lipoprotéines, et/ou favorisent le transport des lipides et la détoxication. L'invention concerne également une méthode de suivi d'une petite molécule chez un mammifère. Les petites molécules de l'invention inhibent, de plus, l'ostéoporose. Lorsqu'elles sont administrées avec une statine, ces petites molécules améliorent l'activité de la statine permettant à la statine d'être utilisée à des doses significativement inférieures, et/ou augmentant significativement la capacité anti-inflammatoire des statines à n'importe quelle dose donnée.

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