Orally administrable extended release pellet and tablet...

A - Human Necessities – 61 – K

Patent

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A61K 9/14 (2006.01)

Patent

CA 2624995

Pharmaceutical compositions comprising an extended release formulation of active compounds effective in the treatment of various pathological conditions are provided. More particularly, the invention provides methods of making and using extended release formulations comprising active compounds that present formulation challenges such as short biological half-life, instability, highly water soluble and/or high dose requirements. Specifically, orally administrable extended release pellet and tablet formulations of isovaleramide are preferred.

La présente invention concerne des compositions pharmaceutiques comportant une formulation à libération prolongée de composés actifs efficaces dans le traitement de diverses conditions pathologiques. Plus particulièrement, l'invention concerne des procédés de fabrication et d'utilisation de formulations à libération prolongée comportant des composés actifs qui résolvent des problèmes de formulation tels que la demi-vie biologique de courte durée, l'instabilité, les exigences d'hydrosolubilité élevée et/ou de doses élevées. De manière spécifique, les formulations préférées sont des formulations de pastille d'administration orale à libération prolongée d'isovaléramide.

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