Orally administrable immediate-release and prolonged-release...

A - Human Necessities – 61 – K

Patent

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A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 31/155 (2006.01) A61K 31/185 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2321267

The present invention relates to an orally administrable galenic form allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in physiological media, comprising at least one such active ingredient, an absorption-promoting agent having an HLB greater than 8, the said absorption-promoting agent consisting of one or more lipid substances chosen from: polysorbates; ethers of polyoxyethylene and alkyl; esters of polyoxyethylene and fatty acids; fatty acids; fatty alcohols- bile acids and their salts with pharmaceutically acceptable cations; esters of C1-C6 alkanol with fatty acids; esters of polyol with fatty acids, the said polyol comprising from 2 to 6 hydroxyl functional groups; and polyglycolysed glycerides; in combination with one or more pharmaceutically acceptable excipients, the pharmaceutical forms comprising captopril being excluded.

La présente invention porte sur une forme galénique s'administrant par voie orale et permettant une meilleure absorption, par voie transmembranaire ou paracellulaire dans les voies gastro-intestinales, des ingrédients actifs qui sont hydrophiles ou ionisables dans des milieux physiologiques. Cette forme galénique comprend au moins un ingrédient actif, un agent favorisant l'absorption dont le rapport hydrophile-lipophile est supérieur à 8, cet agent comprenant une ou plusieurs substances liquides sélectionnées parmi: des polysorbates; des éthers de polyoxyéthylène et alkyle; des esters de polyoxyéthylène et des acides gras; des acides biliaires et leurs sels renfermant des cations pharmaceutiquement acceptables; des esters d'alcanol C1-C6 avec des acides gras; des esters de polyol avec des acides gras, le polyol comprenant 2 à 6 groupes fonctionnels hydroxy; et des glycérides polyglycosylés; en combinaison avec un ou plusieurs excipients pharmaceutiquement acceptables, les formes pharmaceutiques comprenant captopril étant exclues.

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