Orally administrable pharmaceutical compositions

Details Orally administrable pharmaceutical compositions Orally administrable pharmaceutical compositions

A - Human Necessities

61

K

167/153, 167/252

A61K 9/30 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01)

Patent

CA 1172570

ABSTRACT A solid dosage form, such as a capsule or tablet, containing a pharmacologically active agent is coated with an anionic polymer, which is insoluble in gastric juice and in intestinal juice below pH 7 but soluble in colonic intestinal juice, in a sufficient amount that the oral dosage form remains intact until it reaches the colon. The preferred anionic polymer is a partly methyl esterified methacrylic acid polymer in which the ratio of free carboxylic groups to ester groups is about 1:2. The invention has particular application to dosage forms of predaisolone and salts thereof, indomethacin, ibuprofen, and, especially, 5-amino- salicylic hold.

408390

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