A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 38/28 (2006.01) A61K 49/00 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2704712
The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapetucic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.
La présente invention concerne une composition capable d'acheminer un agent thérapeutique ou diagnostique généralement non disponible par voie orale dans l'environnement du tube digestif, de façon à ce que ledit agent thérapeutique ou diagnostique soit biodisponible. La composition peut ou pas être ciblée en direction de récepteurs cellulaires spécifiques, comme les hépatocytes. Parmi lesdits agents thérapeutiques, on peut citer, mais la liste n'est pas limitative, l'insuline, la calcitonine, la sérotonine et d'autres protéines. Le ciblage est réalisé au moyen de biotine ou d'agents de ciblage à base métallique.
Geho W. Blair
Lau John R.
Gowling Lafleur Henderson Llp
Sdg Inc. (an Ohio Corporation)
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