C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/409 (2006.01) A61K 31/555 (2006.01) A61P 25/00 (2006.01) A61P 39/00 (2006.01)
Patent
CA 2528347
The invention relates to compounds which are orally bioavailable water soluble metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halogen substituted alkyl or substituted or unsubstituted phenyl groups, are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.
L'invention concerne des composés formant des métalloporphyrines solubles dans l'eau et biodisponibles par voie orale. Ces composés constituent des épurateurs catalytiques de synthèse d'espèces chimiques d'oxygène réactif. L'invention concerne aussi des compositions pharmaceutiques qui comprennent ces composés et des procédés d'utilisation de ceux-ci pour prévenir ou traiter des maladies ou des états pathologiques associés aux radicaux libres.
Cosledan Frederic
Meunier Bernard
Eukarion Inc.
Fetherstonhaugh & Co.
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