A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 9/48 (2006.01) A61K 31/42 (2006.01) A61K 31/635 (2006.01) A61K 47/10 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) C07D 231/12 (2006.01) C07D 261/08 (2006.01) C07D 413/12 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/22 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2444356
An orally deliverable pharmaceutical composition is provided comprising an aminosulfonyl-comprising drug, for example a selective cyclooxygenase-2 inhibitory drug such as celecoxib, and a solvent liquid comprising a polyethylene glycol and one or more free radical-scavenging antioxidants. At least a substantial part of the drug is in dissolved form in the solvent liquid. The composition has rapid-onset properties and is useful in treatment of cyclooxygenase-2 mediated conditions and disorders.
La présente invention concerne une composition pharmaceutique d'administration orale comportant un médicament contenant un aminosulphonyle, par exemple un médicament inhibiteur sélectif de la cyclo-oxygénase 2 tel que le célécoxib, et un liquide solvant comprenant un polyéthylène glycol et un ou des agents antioxydants capteurs de radicaux libres. Au moins une partie substantielle du médicament se trouve dissoute dans le liquide solvant. La composition présente des propriétés de délai d'action rapide et est utile dans le traitement de conditions et de troubles provoqués par la cyclo-oxygénase 2.
Bauer Juliane M.
Brugger Andrew M.
Forbes James C.
Gao Ping
Guido Jane E.
Pharmacia Corporation
Smart & Biggar
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