Orally-disintegrating solid preparation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2717947

The present invention provides an orally-disintegrating solid preparation such as a tablet produced by tabletting fine granules showing controlled release of a pharmaceutically active ingredient and an additive, and the like, and the orally-disin-tegrating solid preparation containing fine granules coated with a coating layer containing a polymer affording a casting film hav-ing an elongation at break of about 100 - about 700%. With the preparation, breakage of fine granules during tabletting can be suppressed in the production of an orally-disintegrating solid preparation containing fine granules showing controlled release of a pharmaceutically active ingredient.

La présente invention concerne une préparation solide orodispersible de type comprimé obtenu par compression de fines granules à capacité de libération contrôlée d'un principe actif acceptable sur le plan pharmaceutique et d'un additif, et analogues; ladite préparation solide orodispersible contenant de fines granules enrobées d'une couche d'enrobage qui contient un polymère permettant d'obtenir une coulée de film présentant un allongement à la rupture compris entre environ 100 et environ 700 %. Au moyen de ladite préparation, la rupture des fines granules pendant la compression peut être éliminée lors de la production d'une préparation solide orodispersible contenant de fines granules à capacité de libération contrôlée d'un principe actif acceptable sur le plan pharmaceutique.

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