A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2760614
The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked high-dose/low-dose drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of high-dose and low-dose drugs which provide for more convenient and palatable administration of drug combinations, for example for treating pain, hyperglycemia, cardiovascular disease, and allergies.
La présente invention porte sur des compositions pharmaceutiques qui comportent une pluralité de microparticules contenant des médicaments à dose élevée/dose faible à goût masqué, sur des formes galéniques qui comportent de telles compositions pharmaceutiques (telles qu'un comprimé à désintégration orale) et sur des procédés de fabrication des compositions pharmaceutiques et des formes galéniques de la présente invention. Les formes galéniques comportant les compositions pharmaceutiques de la présente invention sont des mélanges homogènes améliorés de médicaments à dose élevée et dose faible qui permettent une administration plus commode et de goût agréable de combinaisons de médicaments, par exemple pour traiter la douleur, l'hyperglycémie, une maladie cardiovasculaire et des allergies.
Clevenger James
Gosselin Michael
Lai Jin-Wang
Venkatesh Gopi M.
Aptalis Pharmatech Inc.
Borden Ladner Gervais Llp
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