Orally disintegrating tablets and methods of manufacture

Details Orally disintegrating tablets and methods of manufacture Orally disintegrating tablets and methods of manufacture

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/34 (2006.01)

Patent

CA 2563440

A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.

L'invention concerne un comprimé se désintégrant rapidement dans la cavité orale et comprenant un mélange comprimé de micro-granulés se dispersant rapidement et préparé par granulation d'un alcool de sucre ou d'un saccharide ou d'un mélange de ceux-ci possédant une granulométrie moyenne inférieure à environ 30 microns et d'un désintégrateur et une microcapsule de saveur masquée renfermant au moins un médicament et étant préparée par granulation d'une formulation acceptable sur le plan pharmaceutique comprenant au moins un médicament dans une quantité efficace sur le plan thérapeutique et au moins un liant polymère améliorant la résilience des micro-granulés, par mouture humide de la masse granulée et par micro-encapsulage des granulés broyés, de manière à obtenir des microcapsules.

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