Orally immunogenic bacterial enterotoxins expressed in...

Details Orally immunogenic bacterial enterotoxins expressed in... Orally immunogenic bacterial enterotoxins expressed in...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01) A61K 39/106 (2006.01) A61K 39/108 (2006.01) A61K 39/39 (2006.01) C07K 14/245 (2006.01) C07K 14/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2359586

The invention provides mutant Escherichia coli heat labile (LT) and Vibrio cholerae toxin (CT) polypeptides and the polynucleotides that encode them. The mutant LT and CT polypeptides can be readily produced in plants and can be used to treat or prevent diseases caused by E. coli and V. cholera. The polypeptides are also useful as adjuvants.

Cette invention concerne des polypeptides mutants des toxines Escherichia coli thermolabiles (LT) et Vibrio cholerae (CT) et les polynucléotides codant pour ces polypeptides. Les polypeptides mutants LT et CT peuvent être produits facilement dans des plantes et conviennent pour le traitement ou la prévention de maladies causées par E. coli et V. cholera. Ces polypeptides sont également utiles en tant qu'adjuvants.

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