Organ-on-a-chip-device

C - Chemistry – Metallurgy – 12 – M

Patent

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Details

C12M 3/00 (2006.01) C12N 5/07 (2010.01) C12Q 1/00 (2006.01) C12N 11/00 (2006.01)

Patent

CA 2727003

The present invention relates to a self-contained sensor controlled organ on a chip-device, which allows establishing or maintaining organs or organoids as well as stem cell niches in a miniaturized chip format, suitable for online observation by live cell imaging and for example two photon microscopy and their use for, e.g. testing the activity, pharmacodynamic and pharmacokinetic of compounds or to study self-assembly, homeostasis, damage, regeneration or interaction of organs or organoids and stem cell niches, as well as phenomena of maturation, aging, death and chronobiology.

La présente invention porte sur un organe commandé par un détecteur auto-contenu sur un dispositif de puce, qui permet d'établir ou de conserver des organes ou organoïdes ainsi que des niches de cellules souches dans un format de puce miniaturisée, approprié pour une observation en ligne par une imagerie de cellules vivantes et par exemple par une microscopie à deux photons et sur leur utilisation, par exemple pour tester l'activité, la pharmacodynamique et la pharmacocinétique de composés ou pour étudier l'auto-assemblage, l'homéostase, le dommage, la régénération ou l'interaction d'organes ou d'organoïdes et de niches de cellules souches, ainsi que des phénomènes de maturation, de vieillissement, de mort et de chronobiologie.

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