A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/04 (2006.01)
Patent
CA 2632777
The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C ~ (PKC ~). Methods for using the inventive solution are also disclosed, including methods for preserving an organ for transplantation, for protecting an ischemic organ from damage, for attenuating organ dysfunction after ischemia, for maintaining nitric oxide release and/or inhibiting superoxide release in an ischemic organ, and for protecting an organ from damage when isolated from the circulatory system.
La présente invention concerne une solution permettant la conservation, la perfusion et/ou la reperfusion d'un organe, en particulier le cAEur, en vue d'une transplantation. La solution contient un ou des inhibiteurs peptidiques de protéine kinase C ÿ (PKC ÿ). La présente invention concerne également des procédés d'utilisation de cette solution, y compris des procédés permettant de conserver un organe en vue d'une transplantation, de protéger un organe ischémique de tout dommage, d'atténuer le dysfonctionnement d'un organe après une ischémie, de maintenir la libération d'oxyde nitrique et/ou d'inhiber la libération de superoxyde dans un organe ischémique et de protéger un organe de tout dommage lors de son isolement du système circulatoire.
Philadelphia College Of Osteopathic Medicine
Ridout & Maybee Llp
LandOfFree
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