C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/00 (2006.01) A01N 43/54 (2006.01) A61K 31/505 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 491/00 (2006.01)
Patent
CA 2611312
The invention provides novel 7,8-dihydro-imidazo[l,2-.alpha.]pyrazolo[4,3- e]pyrimidin-4- one compounds and 7,8,9-trihydro-[lHor 2/f]-pyrimido [l,2- a]pyrazolo[4,3- e]pyrimidin-4(5H)-one compounds, substituted at the 1 or 2 position with C2-g allcyl, C3-9 cycloalkyl, heteroarylalkyl, or substituted arylalkyl, in free, salt or prodrug form, processes for their production, their use as pharmaceuticals, particularly as PDEl inhibitors, and pharmaceutical compositions comprising them.
L'invention concerne de nouveaux composés 7,8-dihydro-imidazo[l,2-a]pyrazolo[4,3-e]pyrimidine-4- one et 7,8,9-trihydro-[lH or 2H]-pyrimido [l,2-a]pyrazolo[4,3- e]pyrimidine-4(5H)-one, substitués à la position 1 ou 2 par C2-9 alkyle, C3-9 cycloalkyle, hétéroarylalkyle, ou arylalkyle substitué, sous forme libre, de sel ou de promédicament, ainsi que leurs procédés de production, leur utilisation comme produits pharmaceutiques, en particulier comme inhibiteurs de PDE1, et des compositions pharmaceutiques les renfermant.
Li Peng
Wu Haiyan
Intra-Cellular Therapies Inc.
Kirby Eades Gale Baker
Li Peng
Wu Haiyan
LandOfFree
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