Organic compounds

Details Organic compounds Organic compounds

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/497 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2685546

A compound of formula (I), or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.

L'invention concerne un composé de formule (I) ou ses tautomères, ses stéréoisomères, ses solvates ou ses sels pharmaceutiquement acceptables. Dans la formule (I), M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 et R5a sont tels que définis dans le présent document. Le composé selon l'invention est destiné au traitement de troubles qui peuvent être traités par le blocage d'un canal sodium épithélial, notamment de troubles qui bénéficient de l'hydratation mucosale.

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