Organic compounds

Details Organic compounds Organic compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2707218

1- or 2- or 7-(substituted)-3-(optionally hetero)arylamino-[1H, 2H]- pyrazolo[3,4-d] pyrimidine-4,6(5H, 7H)-dione derivatives, in free, salt or prodrug form, are useful as pharmaceuticals, particularly as phosphodiesterase 1 inhibitors, useful for the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy and damage to cognitive function, e.g., in schizophrenia or disorders that may be ameliorated through enhanced progesterone - signaling pathway, e.g., female sexual dysfunction.

L'invention porte sur des dérivés de 1- ou 2- ou 7-(substitué)-3-(facultativement hétéro) arylamino-[1H,2H]-pyrazolo[3,4-d] pyrimidine-4,6(5H,7H)-dione, sous forme libre, de sel ou de promédicament, qui s'utilisent comme produits pharmaceutiques, en particulier comme inhibiteurs de la phosphodiestérase 1, et également pour le traitement de maladies entraînant des troubles de la voie intracellulaire des récepteurs de la dopamine D1, telles que la maladie de Parkinson, la dépression, la narcolepsie et une lésion à une fonction cognitive, par exemple dans la schizophrénie ou des troubles qui peuvent être améliorés par une voie de signalisation de la progestérone améliorée, par exemple un dysfonctionnement sexuel chez la femme.

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