C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/61 (2006.01) A61K 31/215 (2006.01) A61K 31/4458 (2006.01) A61P 31/00 (2006.01) C07D 211/60 (2006.01)
Patent
CA 2734392
Compounds of formula (I), which are 14-O-{[(optionally substituted hydroxy)cyclohexyl)sulfanyl]acetyl}mutilins further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical, e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbese are mediating said inflammation.
Composés de formule (I), qui sont des 14-O-{[(hydroxy éventuellement substitué)cyclohexyl)sulfanyl]acétyl}mutilines substituées plus avant au niveau du groupement cyclohexyle par un groupement amino acylé, leurs sels et leur solvates, les compositions pharmaceutiques comprenant de tels composés et leur emploi en tant que produits pharmaceutiques, par exemple dans le traitement de pathologies faisant intervenir des microbes et dans le traitement d'inflammations faisant intervenir des microbes.
Heilmayer Werner
Mang Rosemarie
Nabriva Therapeutics Ag
Ridout & Maybee Llp
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