G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/542 (2006.01)
Patent
CA 2599506
The invention relates to an assay for identifying an agent that modulates the interaction of a mRNA with a target protein, e.g. HuR and to organic compounds of formula (I); wherein R1, R2 and R3 are as defined above, and their use, e.g. as an inhibitor on the complex-formation of an ARE-containing mRNA and a target protein.
Cette invention concerne un dosage destiné à identifier un agent qui module l'interaction d'un ARNm et d'une protéine cible, telle que HuR. Elle concerne des composés organiques de la formule (I), dans laquelle R1, R2 et R3 sont tels que définis dans le mémorandum descriptif, et l'utilisation desdits composés organiques comme inhibiteurs de la formation en complexe d'un ARNm contenant ARE et d'une protéine cible.
Auer Manfred
Gstach Hubert
Hintersteiner Martin
Meisner Nicole-Claudia
Schindler Torsten
Fetherstonhaugh & Co.
Novartis Ag
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