Organic compounds

C - Chemistry – Metallurgy – 12 – P

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Details

C12P 17/08 (2006.01) A61K 31/365 (2006.01) C07D 313/00 (2006.01) C12N 1/14 (2006.01)

Patent

CA 2110553

39 ABSTRACT IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Novel compounds of formula I Image I wherein R4, R5, R6, -a-b-, c, -d-e- and -f-g- are as defined are cytokine release inhibitors and IL-1 antagonists and are thus indicated for treatment of disorders with an aetiology associated with or comprising excessive cytokine release, particularly IL-1.beta. release, including a wide variety of inflammatory states and diseases such as RA, osteoarthritis, septic shock, psoriasis, atherosclerosis, inflammatory bowel disease, Crohn's disease and asthma. Related known compounds Zearalenone and radicicol and derivatives thereof have also been found to have cytokine release inhibitor properties and have similar pharmaceutical applications.

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