C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/08 (2006.01) A61K 31/365 (2006.01) C07D 313/00 (2006.01) C12N 1/14 (2006.01)
Patent
CA 2110553
39 ABSTRACT IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Novel compounds of formula I Image I wherein R4, R5, R6, -a-b-, c, -d-e- and -f-g- are as defined are cytokine release inhibitors and IL-1 antagonists and are thus indicated for treatment of disorders with an aetiology associated with or comprising excessive cytokine release, particularly IL-1.beta. release, including a wide variety of inflammatory states and diseases such as RA, osteoarthritis, septic shock, psoriasis, atherosclerosis, inflammatory bowel disease, Crohn's disease and asthma. Related known compounds Zearalenone and radicicol and derivatives thereof have also been found to have cytokine release inhibitor properties and have similar pharmaceutical applications.
Dreyfuss Michael M.
Leutwiler Albert
Mackenzie Andrew R.
Mattes Henri
Schnyder Jorg
Dreyfuss Michael M.
Kirby Eades Gale Baker
Leutwiler Albert
Mackenzie Andrew R.
Mattes Henri
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