Organic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61K 31/497 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2661017

The present invention relates generally to the field of inhibitors of stearoyl-CoA desaturase, such as heterocyclic derivatives, and uses for such compounds in treating and/or preventing various human diseases, including ihose mediated by stearoyl-CoA desaturase (SCD) enzymes, preferably SCDl, especially diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, dermatological disorders and the like. The invention provides compounds of formula (I): X is N or CH; Y is NH, O, S or N-CH3; Q is formulae (a), (b), ou (c).

La présente invention concerne des dérivés hétérocycliques qui modulent l'activité de la stéaroyl-CoA désaturase. L'invention concerne également des procédés d'utilisation de tels dérivés pour moduler l'activité de la stéaroyl-CoA désaturase et des compositions pharmaceutiques comprenant de tels dérivés.

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