A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/4015 (2006.01)
Patent
CA 2708083
A process for reducing the tendency of a drug substance to aggregate and/or agglomerate during storage. The process involves micronising the drug substance to give a mean particle size of less than about 10 µm, and exposing the micronised drug substance to a dry environment at an elevated temperature between 40° C and 120° C for at least six hours.
Le procédé de l'invention permet de réduire la tendance d'une substance médicamenteuse à s'agréger et/ou à s'agglomérer en stockage. Le procédé implique la micronisation de la substance médicamenteuse pour obtenir une taille de particules moyenne inférieure à environ 10 µm, et l'exposition de la substance médicamenteuse micronisée à un environnement sec à une température élevée comprise entre 40 et 120°C pendant au moins six heures.
Juhnke Michael
Muhrer Gerhard
Rasenack Norbert
Fetherstonhaugh & Co.
Novartis Ag
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