Organic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2411778

The present invention relates to certain N-(substituted glycyl)-2- cyanopyrrolidines of formula (I) wherein Y is as defined herein, in free form or in acid addition salt form. Compounds of formula (I) inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

L'invention concerne des N-(glycyle substitué)-2-cyanopyrrolidines particulières représentées par la formule (I) dans laquelle Y est tel que défini dans le descriptif, sous forme libre ou sous forme de sel d'addition acide. Ces composés inhibent l'activité de la DPP-IV (dipeptidyl-peptidase-IV). Ils sont par conséquent indiqués en tant que médicaments inhibiteurs de DPP-IV et permettant de traiter des pathologies dans lesquelles la DPP-IV joue un rôle de médiateur telles que le diabète non insulinodépendant, l'arthrite, l'obésité, l'ostéoporose et d'autres états associés à une tolérance réduite au glucose.

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