A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01)
Patent
CA 2707594
A process of preparing a particulate and substantially crystalline drug substance. The process involves suspending a substantially crystalline drug substance in an anti-solvent to give a suspension, homogenising the suspension at elevated pressure to give drug particles that have a mean particle size of less than about 10 µm, and drying the drug particles to remove any residual anti-solvent.
L'invention porte sur un procédé de préparation d'une substance médicamenteuse particulaire et sensiblement cristalline. Le procédé met en jeu les opérations consistant à mettre en suspension une substance médicamenteuse sensiblement cristalline dans un anti-solvant pour donner une suspension, homogénéiser la suspension à une pression élevée pour donner des particules de médicament qui ont une dimension moyenne de particule de moins d'environ 10 µm, et sécher les particules de médicament pour retirer tout antisolvant résiduel.
Kieckbusch Thomas
Muhrer Gerhard
Rasenack Norbert
Schaffluetzel Kurt
Singh Dilraj
Fetherstonhaugh & Co.
Novartis Ag
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