Organic compounds and their pharmaceutical use

Details Organic compounds and their pharmaceutical use Organic compounds and their pharmaceutical use

C - Chemistry, Metallurgy

07

C

167/179, 260/312

C07C 317/18 (2006.01) A61K 31/10 (2006.01) A61K 31/41 (2006.01) C07C 17/26 (2006.01) C07C 17/354 (2006.01) C07C 33/20 (2006.01) C07C 33/30 (2006.01) C07C 323/16 (2006.01) C07D 257/04 (2006.01) C07D 303/04 (2006.01) C07D 303/14 (2006.01) C07D 303/32 (2006.01) C07D 303/38 (2006.01) C07D 303/40 (2006.01) C07D 307/88 (2006.01) C07D 309/12 (2006.01) C07D 405/10 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1297632

NOVEL ORGANIC COMPOUNDS AND THEIR PHARMACEUTICAL USE ABSTRACT OF THE INVENTION There are described compounds of formula Image (I) in which n is 0, 1 or 2, R1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R2 is optionally substituted phenyl or C1-10alkyl optionally substituted by one or more substituents selected from optionally protected hydroxyl, optionally protected carboxyl, nitrile, optionally protected tetrazolyl, -COR6 where R6 is C1-4alkyl, C1-4alkoxy, an optionally protected amino acid residue or -NR? where each R7 is hydrogen or C1-4alkyl, and -NHR9 where R8 is hydrogen, a protecting group, an optionally protected amino acid residue, C1-4alkyl or -COR9 where R9 is C1-4alkyl or C1-4alkoxy, and R3, R4 and R5 are each selected from hydrogen, carboxyl, C2-5 alkoxycarbonyl, C1-4alkyl, C1-4alkoxy, hydroxyl, optionally protected tetrazolyl, halo, trifluoromethyl, nitrile, nitro and -CONR? where each R10 is hydrogen or C1-4 alkyl; and salts thereof. The compounds are leukotriene antagonists.

459715

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