C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61P 7/02 (2006.01) C07K 14/81 (2006.01) G01N 33/50 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2513466
The invention relates to biologically active molecules, which interact with thrombin and inhibit the same. The invention particularly relates to molecules of the general formula Y1-(NH-X1-C=O)-(NH-X2-C=O)-(NH-X3-C=O)-(NH-X4-C=O)-(NH- X5-C=O) (NH- X6-C=O)-Y2 , wherein Y1, Y2 and X1-6 have the meanings given in the description and N- or C-terminal abbreviated variations of said compounds and the use thereof for the production of medicaments.
L'invention concerne des molécules bioactives interagissant avec la thrombine et inhibant cette dernière. Ladite invention concerne en particulier des molécules de formule générale (I) Y?1¿-(NH-X?1¿-C=O)-(NH-X?2¿-C=O)-(NH-X?3¿-C=O)-(NH-X?4¿-C=O)-(NH-X?5¿-C=O) (NH- X?6¿-C=O)-Y?2¿, dans laquelle Y?1¿, Y?2¿ et X?1-6¿ ont les significations mentionnées dans la description, des variantes tronquées N- ou C-terminal de ces composés et l'utilisation de ces derniers dans la production de médicaments.
Schwienhorst Andreas
Thuerk Marcel
Cpi Creative Pharma International Gmbh
Robic
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