Organic-inorganic hybrid particles containing contrast agent

Details Organic-inorganic hybrid particles containing contrast agent Organic-inorganic hybrid particles containing contrast agent

C - Chemistry, Metallurgy

08

L

C08L 101/08 (2006.01) A61K 47/30 (2006.01) A61K 49/00 (2006.01) C08L 53/00 (2006.01) C08L 71/02 (2006.01) C08L 77/04 (2006.01)

Patent

CA 2707233

This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO4 3-) or carbonate ion (CO3 2-), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.

L'invention concerne des particules hybrides organiques-inorganiques comprenant, comme composants essentiels, un copolymère à blocs contenant un segment de chaîne polymère hydrophile non chargé et un segment de chaîne polymère comprenant une unité de répétition ayant un groupe d'ion carboxylate dans une chaîne latérale de celui-ci, un ion calcium (Ca<SUP>2+</SUP>) et un ion phosphate (PO<SUB>4</SUB> <SUP>3-</SUP>

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