Orodispersible tablets

Details Orodispersible tablets Orodispersible tablets

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/551 (2006.01)

Patent

CA 2703501

This invention relates to a an orally disintegrating tablet obtainable by direct compression of a dry powdered mix-ture, said mixture comprising up to 15% by weight of calcium silicate, at least 50% of a diluent, a disintegrant agent and an active ingredient. It also relates to a process for preparing the tablets by homogeneous blending the specific excipients in powder form and subsequent direct compression of the mixture. Said tablets disintegrate quickly in the cavity of the mouth, in particular in less than 15 seconds.

Comprimé à désintégration orale pouvant être obtenu par compression directe d'un mélange en poudre sec. Ledit mélange comprend jusqu'à 10% en poids de silicate de calcium,au moins 50% d'un diluant, un agent désintégrant et un principe actif. L'invention concerne également un procédé de fabrication des comprimés par réalisation d'un mélange homogène des excipients spécifique sous forme de poudre et compression subséquente directe du mélange. Lesdits comprimés se désintégrent rapidement dans la cavité buccale, spécifiquement en moins de 15 secondes

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