C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/496 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 417/04 (2006.01) C07D 453/02 (2006.01) C12N 9/99 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2517291
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie- 2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
La présente invention concerne des composés destinés à moduler l'activité enzymatique de la protéine kinase afin de moduler les activités cellulaires telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chémoinvasion. Les composés de l'invention inhibent, régulent et/ou modulent les kinases, en particulier Tie-2. Des procédés d'utilisation des composés et de leurs compositions pharmaceutiques, pour traiter des maladies et des états liés à la kinase, sont également un aspect de l'invention.
Bannen Lynne Canne
Brown S. David
Cheng Wei
Cheung Atwood Kim
Dalrymple Lisa Esther
Bennett Jones Llp
Exelixis Inc.
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