C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/22 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 323/42 (2006.01) C07D 207/337 (2006.01) C07D 213/58 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2198980
Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Ortho-substituted benzoylguanidines of the formula I Image in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.
Benzoylguanidines substituées en ortho, procédé de préparation, utilisation comme médicament ou produit diagnostique, et médicament les contenant. Les benzoylguanidines substituées en ortho de la formule I Image dans laquelle R(1) à R(4) ont les significations indiquées dans les revendications, conviennent comme produits pharmaceutiques antiarythmiques ayant une composante cardioprotectrice, pour la prévention et le traitement de l'infarctus et pour le traitement de l'angine de poitrine. Elles inhibent également, de manière préventive, les processus patho-physiologiques associés à la genèse de lésions induites par l'ischémie, en particulier liées au déclenchement des arythmies cardiaques induites par l'ischémie.
Albus Udo
Brendel Joachim
Kleemann Heinz-Werner
Lang Hans Jochen
Scholz Wolfgang
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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