Ortho-substituted nitrogen-containing bisaryl compounds used...

Details Ortho-substituted nitrogen-containing bisaryl compounds used... Ortho-substituted nitrogen-containing bisaryl compounds used...

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/497 (2006.01) A61P 9/06 (2006.01) C07D 213/56 (2006.01) C07D 213/82 (2006.01) C07D 241/24 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2436891

Compounds of formula (I) wherein A1 - A8, R(1), R(2), R(3), R(4), R(30) and R(31) have the meanings cited in the claims. Said compounds are particularly suitable for use as novel antiarrythmic substances, especially in the treatment and prophylaxis of atrial arrhythmia, for example, atrial fibrillation (AF) or atrial flutter.

Les composés de la formule générale (I) dans laquelle A1 à A8, R(1), R(2), R(3), R(4), R(30) et R(31) ont la signification donnée dans le descriptif, sont particulièrement adaptés à une utilisation en tant qu'agents antiarythmiques, notamment pour le traitement et la prophylaxie d'arythmies de l'oreillette par ex. de fibrillations auriculaires ou de flutter auriculaire.

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