C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/381.3, 260/5
C07D 333/22 (2006.01) C07D 213/53 (2006.01) C07D 213/89 (2006.01) C07D 307/52 (2006.01) C07D 317/66 (2006.01)
Patent
CA 1186325
ABSTRACT OF THE DISCLOSURE Compounds, exhibiting central nervous system activity, of the formula Image (I) wherein R1 is phenyl which is unsubstituted or substituted by at least one member selected from the group consisting of halogen, CF3, C1-C4 alkyl, C1-C4 alkoxy and COOH, or Image R1 is a heterocycle selected from the group consisting of Image R2, R3, R4 and R5, which may be identical or different, are H or CH3; R6 and R7, which may be identical or different, are C1-C6 alkyl, which may be straight-chained or branched, or R7 can be H when R6 is a branched-chain alkyl, or R6 and R7 can form, with the nitrogen to which they are bonded, a heterocycle selected from the group consisting of Image R8, R9, R10 and R11, which may be identical or different, are H, halogen, CF3, hydroxy or C1-C4 alkoxy; and two contiguous members of R8, R9, R10 and R11 may together form a chain -O-(CH2)n-O-, where n = 1 or 2, or a chain -O-CH2-O-CH2-; and pharmaceutically acceptable addition salts thereof are disclosed, along with a method of producing the same, and pharmaceutical compositions comprising the same.
370905
Creuzet Marie-Helene
Feniou Claude
Guichard Francoise
Prat Gisele
Laboratoires Sarget
Swabey Ogilvy Renault
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