C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/72 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2543329
The present invention relates to an orthogonal gene switch for regulating the expression of a desired gene. The gene switch comprises a chimeric transcription factor that does not respond to endogenous ligands, and a ligand that is capable of activating the chimeric transcription factor but not endogenous transcription factors. The present invention also relates to the method of constructing the orthogonal gene switch.
L'invention concerne un commutateur génique orthogonal permettant de réguler l'expression d'un gène voulu. Ce commutateur génique comprend un facteur de transcription chimère ne réagissant pas aux ligands endogènes, et un ligand pouvant activer le facteur de transcription chimère mais pas les facteurs de transcription endogènes. L'invention concerne aussi un procédé de construction du commutateur génique orthogonal.
Ciliberto Gennaro
Cortese Riccardo
de Francesco Raffaele
Fattori Daniela
Gallinari Paola
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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