C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C12N 9/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2583735
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli,or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
L'invention concerne des paires orthogonales d'ARNt et des synthétases d'aminoacyle-ARNt pouvant intégrer des acides aminés non naturels dans des protéines produites dans des cellules hôtes eubactériennes notamment en E.coli, ou dans un hôte eucaryote, notamment une cellule de levure. L'invention concerne par exemple, de manière non exhaustive, de nouvelles synthétases orthogonales, des méthodes pour identifier et pour fabriquer de nouvelles synthétases, des méthodes pour produire des protéines contenant des acides aminés non naturels, et des systèmes de translation.
Alfonta Lital
Chittuluru Jonathan R.
Deiters Alexander
Groff Dan
Schultz Peter
Fetherstonhaugh & Co.
The Scripps Research Institute
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