C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2410394
Methods for identifying modulators of receptor activity using orthologues of human receptors are described. Additionally, a method for identifying an animal model useful in the screening of potential therapeutic agents is provided. The genes for bradykinin B1 receptors from five mammalian species, vervet monkey, rhesus macaque, tree shrew, dog and pig, as well as the genes for CXCR2 receptors from chimpanzee, gorilla, orangutan, rhesus, vervet and baboon have been cloned and characterized and are described herein.
La présente invention concerne des procédés permettant d'identifier les modulateurs de l'activité d'un récepteur au moyen d'orthologues de récepteurs humains. L'invention concerne également un procédé d'identification d'un modèle animal convenant à la recherche systématique d'agents thérapeutiques potentiels. L'invention concerne plus particulièrement le clonage et la caractérisation, non seulement des gènes des récepteurs de la bradykinine B¿1? de cinq espèces de mammifères (singe vert, macaque rhésus, musaraigne d'arbres, chien et cochon), mais également des gènes des récepteurs CXCR2 du chimpanzé, du gorille, de l'orang-outan, rhésus, singe vert et babouin.
Auld Douglas S.
Baldwin John J.
Chen Xiao Ge
Horlick Robert
Strohl Barbara
Gowling Lafleur Henderson Llp
Pharmacopeia Inc.
Pharmacopeia Drug Discovery Inc.
LandOfFree
Orthologues of human receptors and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Orthologues of human receptors and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orthologues of human receptors and methods of use will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1668945