A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) A61F 2/44 (2006.01)
Patent
CA 2583911
Implantable prosthetic devices are provided for controlled drug delivery, for orthopedic and dental applications. The device may include a prosthetic device body having at least one outer surface area; two or more discrete reservoirs located in spaced apart positions across at least a portion of the outer surface area, the reservoirs formed with an opening at the surface of the device body and extending into the device body; and a release system disposed in the reservoirs which comprises at least one therapeutic or prophylactic agent, wherein following implantation into a patient the therapeutic or prophylactic agent is released in a controlled manner from the reservoirs. The prosthetic device body preferably is a joint prosthesis or part thereof, such as a hip prosthesis, a knee prosthesis, a vertebral or spinal disc prosthesis, or part thereof. Optional reservoir caps may further control release kinetics.
La présente invention a pour objet des prothèses dentaires ou orthopédiques permettant le relargage réglé d~un médicament. Une prothèse peut inclure un corps principal avec au moins une surface externe ; au moins deux réservoirs discrets situés en deux endroits éloignés sur la surface externe et disposant d'une ouverture donnant sur le corps principal ; et un système de relargage disposé dans les réservoirs qui comprend au moins un agent prophylactique ou thérapeutique libéré chez le patient suivant un rythme réglé après l~implantation de la prothèse. Le corps principal est de préférence une articulation ou une partie d~une articulation, telle qu~une prothèse de hanche, de genou, de vertèbre, ou d~une partie de ces dernières. D~éventuelles capsules de réserve permettent également le règlement de la cinétique de relargage.
Cima Michael J.
Hutchinson Charles E.
Santini John T. Jr.
Staples Mark Andrew
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Microchips Inc.
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