Orthopoxvirus vectors, genes and products thereof

Details Orthopoxvirus vectors, genes and products thereof Orthopoxvirus vectors, genes and products thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 38/16 (2006.01) A61K 39/285 (2006.01) C07K 14/07 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2497750

An orthopoxvirus vector, such as vaccinia, is described in which the A52R protein from vaccinia, or a closely related protein from any orthopoxvirus is not expressed or is expressed but is non-functional. Also described is the use of a vaccinia virus A52R protein or a closely related protein from any orthopoxvirus, or a functional peptide, peptidometic, fragment or derivative thereof, or a DNA vector expressing any of the above in the modulation and/or inhibition of IL1R/TLR superfamily signalling.

Cette invention décrit un vecteur d'orthopoxvirus, par exemple de la vaccine, où la protéine A52R provenant de la vaccine ou une protéine étroitement apparentée provenant d'un orthopoxvirus soit n'est pas exprimée soit est exprimée sans être fonctionnelle. Cette invention décrit également l'utilisation d'une protéine A52R de virus de vaccine ou une protéine étroitement apparentée provenant d'un orthopoxvirus, ou un peptide, un peptidométique, un fragment ou un dérivé fonctionnel d'une telle protéine, ou un vecteur d'ADN exprimant l'un des composés mentionnés ci-dessus dans la modulation et/ou l'inhibition de la signalisation de la superfamille IL1R/TLR.

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