C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/863 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 39/285 (2006.01) A61K 48/00 (2006.01) C07K 14/07 (2006.01) C12N 7/04 (2006.01) C12N 15/39 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2499871
An orthopoxvirus vector, such as vaccinia, is described in which the A46R protein from vaccinia, or a closely related protein from any orthopoxvirus is not expressed or is expressed but is non-functional. Also described is the use of a vaccinia virus A46R protein or a closely related protein from any orthopoxvirus, or a functional peptide, peptidometic, fragment or derivative thereof, or a DNA vector expressing any of the above in the modulation and/or inhibition of IL1R/TLR superfamily signalling.
L'invention concerne un vecteur d'orthopoxvirus, notamment une vaccine, dans lequel la protéine A46R provenant de la vaccine, ou une protéine étroitement associée provenant d'un orthopoxvirus quelconque n'est pas exprimée ou est exprimée mais n'est pas fonctionnelle. L'invention concerne également l'utilisation d'une protéine A46R du virus de vaccine ou d'une protéine étroitement associée provenant d'un orthopoxvirus quelconque ou un peptide fonctionnel, ou son peptidométique, fragment ou dérivé, ou un vecteur d'ADN exprimant un des éléments précités dans la modulation et/ou l'inhibition de la signalisation de la superfamille IL1R/TLR.
Bowie Andrew Graham
Haga Ismar Rocha
O'neill Luke Anthony John
Smith Geoffrey Lilley
Stack Julianne
Moffat & Co.
The Provost Fellows And Scholars Of The College Of The Holy And Undivid Ed T
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