C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2291698
This application relates to the cloning of the cDNA encoding Osteoblast Specific Factor-2 (OSF2), and applications of it. OSF2 is shown to be encoded by the CBFA1 locus, but differs, in its 5'-terminus, from the original CBFA1 transcript. Osf2 mRNA is further shown to exist as two splice variants. The characterisation of the functional domains of OSF2 is also described, as well as the phenotype of OSF2 transgenic animals. OSF2 was previously identified in osteoblast cell nuclear extracts, as a specific activity binding to OSE2, one of two Osteoblast Specific promoter Elements identified in the osteocalcin gene promoter.
Procédés et compositions contenant un nouveau facteur de transcription spécifique pour l'ostéoblaste désigné Osf2/Cbfa1. L'invention concerne également des segments d'acide nucléique codant le polypeptide dérivé de lignes de cellules humaines, ainsi que l'utilisation de ces polynucléotides dans une variété de domaines thérapeutiques et diagnostiques. Elle concerne, de plus, des procédés, des compositions, des trousses et des dispositifs servant à identifier des composés inhibiteurs de la différenciation des ostéoblastes, ainsi qu'à identifier des polynucléotides et des polypeptides d'Osf2/Cbfal dans un spécimen. Elle concerne encore des compositions d'acide nucléique contenant un promoteur d'Osf2 et l'utilisation de ce promoteur dans la transcription génétique homologue et hétérologue et la production de protéines.
Ducy Patricia
Karsenty Gerard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Board Of Regents Of The University Of Texas System
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