Osmium-containing redox mediator

Details Osmium-containing redox mediator Osmium-containing redox mediator

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) C12Q 1/54 (2006.01)

Patent

CA 2212828

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors is presented. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solubility in aqueous medium. The figure shows is a cyclic voltammagram of the compound [Os(III)(bpy)2imCl]Cl2, wherein im is imidazolyl. These mediator compounds are particularly useful as a component of a reagent for measuring analytes from a biological fluid, such as blood.

L'invention présente un nouveau groupe de composés à base d'osmium (II) et osmium (III) efficaces en tant que médiateurs redox dans des biocapteurs électrochimiques. Ces composés présentent 1) un faible potentiel d'oxydation, 2) une cinétique de réaction rapide entre le centre électro-actif d'une enzyme et le composé, 3) une oxydation lente de l'osmium par l'oxygène et 4) une remarquable solubilité en milieu aqueux. La figure représente un voltampérogramme cyclique du composé [Os(III)(bpy)2imCl]C12, où im est imidazolyl. Ces composés médiateurs s'avèrent des plus utiles comme constituant d'un réactif permettant de mesurer des analytes provenant d'un fluide biologique, tel que le sang.

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