Osmotic delivery system

Details Osmotic delivery system Osmotic delivery system

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2474425

An osmotic pharmaceutical tablet is described which comprises a single-layer compressed core surrounded by a water permeable layer having a passageway. The single-layer core contains (i) a non-ripening drug having a solubility per dose less than about 1 mL-1, (ii) about 2.0% to about 20% by weight of a hydroxyethylcellulose having a weight-average, molecular weight from about 300,000 to about 2,000,000, and (iii) an osmagent.

L'invention concerne un comprimé pharmaceutique osmotique comprenant un noyau comprimé monocouche enrobé d'une couche perméable à l'eau pourvue d'un passage. Le noyau monocouche contient (i) un médicament de non maturation dont la solubilité par dose est inférieure à environ 1 mL?-1¿, (ii) environ 2,0 % à environ 20 % en poids d'hydroxyéthylcellulose ayant un poids moléculaire moyen en poids se situant entre environ 300 000 et environ 2 000 000, et (iii) un agent osmotique.

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