A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01)
Patent
CA 2520766
The present invention includes devices and methods for reducing the start-up time of osmotically driven drug delivery systems capable of delivering a desired drug at a controlled rate over time. In particular, the present invention includes osmotic pumps that have a preloaded membrane, which includes a semipermeable material that has been preloaded with a nonaqueous, incompressible liquid filler that is miscible with water. The present invention further includes methods for making such osmotic pumps. The preloaded membranes included in the osmotic pumps according to the present invention have proven to provide significant decreases in average start-up times relative to osmotic pumps that include semipermeable membranes that are not preloaded.
L'invention concerne des dispositifs et des procédés de réduction du temps de démarrage de systèmes de libération de médicament osmotique pouvant libérer un médicament voulu à une vitesse contrôlée dans le temps. L'invention porte notamment sur des pompes osmotiques possédant une membrane préchargée se composant d'un matériau semi-imperméable préchargé de matière de remplissage liquide incompressible, non aqueuse et miscible avec l'eau. L'invention se rapporte encore à des procédés de fabrication desdites pompes osmotiques. On a constaté que les membranes préchargées incluses dans les pompes osmotiques de l'invention réduisaient sensiblement les temps de démarrage moyens des pompes osmotiques comprenant des membranes semi-perméables non préchargées.
Berry Stephen A.
Fereira Pamela J.
Lautenbach Scott D.
Alza Corporation
Smart & Biggar
LandOfFree
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